CEACAM5 and neoplasm: Multivariate analysis identified younger age (OR=0.946, p=0.004), smaller tumor circumference in the intestinal lumen (OR=2.809, p=0.046), non-mucinous adenocarcinoma pathological type (OR=10.405, p=0.029), and lower pre-nCRT serum CEA levels (OR=2.463, p=0.031) as independent predictors of achieving pCR following nCRT in locally advanced rectal cancer (Table 8).