TMEM106B and dementia: In particular, TMEM106B protein levels were strongly related to odds of dementia (p = 0.0004) and lower level of cognitive function at baseline (p = 0.007), as well as to worse motor function (motor function at baseline, p = 0.001; slopes of decline, p < 10−5) and more Parkinsonian signs (baseline, p = 0.01; slopes, p < 10−5).