Perhaps most interesting, rs4844620 (which was identified in the ROSMAP GWAS, the ROSMAP/BDR meta-analysis, and exhibited cis-eQTL effects for CD46 in the bulk RNA-Seq and snRNA-Seq, as described above), was associated with lower level of baseline cognition (β=-0.10, p = 0.030), faster slopes of cognitive decline (β=-0.01, p = 0.007), and with greater level of Parkinsonian signs at baseline (β = 0.11, p = 0.04), indicating pleiotropic relations with cognitive and motor phenotypes. The gene discussed is CD46; the disease is Mental deterioration.