Additionally, CLYBL (Citramalyl-CoA Lyase) was prioritized as a predictor of the PhenoAge clock; we found that a loci (rs9557340) in the CLYBL gene was related to cortical clock age and was strongly related to AD neuropathologies and to cognition – suggesting clinical relevance of CLYBL gene to brain aging. The gene discussed is CLYBL; the disease is Alzheimer disease.