To explore the potential roles of Nrf2 in tumor growth, we compared the tumor growth and survival of Nrf2−/−, WT, and Nrf2Tg mice injected subcutaneously with B16F10 melanoma, EL4 lymphoma, MC38 colon carcinoma, or TC-1 lung carcinoma cells. The gene discussed is NFE2L2; the disease is colon carcinoma.