Next, to assess whether Nrf2 expression affects the anti-tumor T cell response, we used Nrf2-deficient (Nrf2−/−) and Nrf2-transgenic (Tg) mice, in which Nrf2 was overexpressed under the control of the human CD2 (hCD2) promoter (Figures S2A–S2C). The gene discussed is NFE2L2; the disease is neoplasm.