TOX and cancer: Knockdown experiments revealed that TOX promotes T‐cell exhaustion by upregulating inhibitory molecules in cancer cells, leading to an increase in the expression of PD‐1, CTLA‐4, Tim‐3, and TIGIT, while inhibition of TOX has been found to reduce T‐cell exhaustion and improve ICB efficacy,23 indicating that TOX stimulates Tpex cells to differentiate into Tex‐term cells.