Besides ribosome proteins, downregulated Pax1 in CBC, EpC, MuC, Anxa1 in CBC, EpC, upregulated Prdx5 in MuC of aged CVP, and downregulated Hmgb1/2 in CBC, EpC, SEC, Prdx5 in EpC, Foxe1 in BC, CBC, EpC, MuC, SEC, upregulated Csnk2b in BC, CBC, SEC, TPC of the aged FLP were hubs in the TF network (Figure 5b, d–f). This evidence concerns the gene HMGB1 and breast cancer.