HDAC5 and cancer: A tumor suppressor activity was also demonstrated for miR-532-3p that, by targeting FOXP3, can inhibit the growth of NSCLC cell models [24] and for miR-589-5p, which, since it usually inhibits Histone deacetylases 5 (HDAC5), when downregulated leads to an overexpression of HDAC5 and therefore to an increase in cancer cell proliferation [25].