TGFB1 and neoplasm: M2 TAMs, which are mainly involved in tissue repair and phagocytosis, typically exhibit tumor-promoting phenotype and immunosuppressive effects that promote tumor development and contribute to tissue repair processes and express high levels of anti-inflammatory and tumor angiogenesis factors: IL-10, programmed death-ligand 1 (PD-L1), transforming growth factor-β (TGF-β), vascular endothelial growth factor (VEGF), some growth factors, different scavenger receptors (CD163 and CD204), and arginase-1 [22, 23].