Further, to verify the role of ferritinophagy, cellular iron levels and mitochondrial dysfunction in PHKG2-promoted ferroptosis after radiotherapy, we constructed the NSCLC in situ transplantation tumor model again as described in the Methods section, followed by radiotherapy or/and drug treatment 7 days after tumor cell injection: oe-NC, oe-NC + radiotherapy, oe-PHKG2 + radiotherapy, oe-PHKG2 + DFO + radiotherapy and oe-PHKG2 + idebenone + radiotherapy. The gene discussed is PHKG2; the disease is non-small cell lung carcinoma.