PHKG2 and non-small cell lung carcinoma: Meanwhile, consistent with the in vitro results, the ferritinophagy (Fig. 6B), intra-tissue iron levels (Fig. 6C) and ferroptosis marker levels (Fig. 6E) were notably lower in the presence of PHKG2 knockdown under radiotherapy treatment accompanied by superior mitochondrial function (low level of mitochondrial depolarization) (Fig. 6D), suggesting that the effect of knockdown of PHKG2 on NSCLC radioresistance was related to ferritinophagy and mitochondria-dependent ferroptosis.