To investigate the role of the NRF2/PHKG2 axis in regulating the sensitivity/resistance to NSCLC radiotherapy, we constructed an NSCLC in situ transplantation model as described in the Methods section and treated mice with sh-NC, sh-NC + radiotherapy, sh-PHKG2 + radiotherapy, sh-NC + ML385 + RT or sh-PHKG2 + ML385 + radiotherapy. The gene discussed is NFE2L2; the disease is non-small cell lung carcinoma.