We performed Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and found the enrichment of extracellular matrix–receptor interaction, focal adhesion, PI3K-Akt signaling pathway, cell cycle, proteoglycans in cancer, cell adhesion molecules, AMPK and Hippo signaling pathways, and ribosome pathway to be altered between EcE and EuE tissues (Supplementary Figs. 10 and 11). This evidence concerns the gene PRKAA1 and cancer.