Healthy colon epithelia and CRC tumours were scored for levels of LGR5 expression on a scale of 0–3 in β-catenin positive cells: a score of 0 corresponds to the absence of any signal; 1 corresponds to low signal in less than 20% of cells; 2 is either higher signal for LGR5 and/or signal in greater than 20% of cells; and 3 is higher signal for LGR5 in greater than 20% of cells. Here, LGR5 is linked to colorectal carcinoma.