We were able to distinguish HCC tumoral sub-groups based on LGR5 protein expression: the non-proliferation sub-class of HCC is dominated by activating mutations in the Wnt pathway component β-catenin (or in rare cases AXIN1), lack of AFP expression and relatively low proliferation rates (Zucman-rossi et al, 2015). The gene discussed is AFP; the disease is hepatocellular carcinoma.