We also observed enhanced differential killing of high LGR5 versus low LGR5 expressing preB-ALL cell lines (NALM6 and 697 cells, respectively; EV4A) and CRC cell lines (LoVo and SW480 cells, respectively; EV4B) by LGR5scFv-CAR-T cells. This evidence concerns the gene LGR5 and acute lymphoblastic leukemia.