Similarly, the high LGR5 expressing CRH patient-derived preB-ALL model demonstrated enhanced sensitivity to LGR5scFv-CAR-T cell killing versus T cells alone, whereas the low LGR5 expressing LC2 model was equally sensitive to LGR5scFv-CAR-T cell and T cell killing (EV4C). This evidence concerns the gene CRH and acute lymphoblastic leukemia.