LGR5 and neoplasm: Of the 213 scored biopsies on the TMA, LGR5 overexpression is apparent in 80% of the tumour samples; however, we observe no significant differences between tumour stages (Fig. 2B) and other phenotypic metrics evaluated for the Bern CRC TMA that include patient age and gender groups, tumour location or the presence of microsatellite instability.