We note the prominent differences between the results obtained from ours and previous transcript analyses of LGR5 and α-LGR5-defined LGR5 protein expression exemplified in brain and ovarian cancers; both malignancies consistently score high for LGR5 transcript levels, however, we detected only low LGR5 protein levels in few cells, in less than 10% of the tumours. Here, LGR5 is linked to neoplasm.