For instance, a single mutation, N72D, was discovered to enhance the binding affinity of IL-15 to IL-2Rβ by around 10-fold.365 This mutated form was then fused with IL-15Rα and Fc, resulting in the development of ALT-803, which exhibited promising results in preclinical studies involving various tumor models.366–368. The gene discussed is IL2RB; the disease is neoplasm.