EGFR and neoplasm: For example, by fusing Neo2A with a HER2 binding protein and Neo2B with an epidermal growth factor receptor (EGFR) binding protein, this design functions like an ‘AND’ logic-gate, as the IL-2 mimic is activated only when both tumor-associated antigens are present within the cells or neighboring cells in the TME, bringing the two components close together (Fig. 14b).