By knocking down either lncTCF7 or SND1, which ablated the SWI/SNF localization to the TCF7 promoter, we demonstrated that lncTCF7 regulates TCF7 transcription in glioblastoma cells through recruiting the SWI/SNF chromatin remodeling complex to its promoter region, and that SND1 is also required in this process. The gene discussed is TCF7; the disease is glioblastoma.