The function of PI3Kα in cilia disassembly identified here, the cilia-related phenotypes of Pik3caH1047R embryos and the presence of polydactyly and renal cysts in PROS provide supporting evidence to speculate PROS may be classified as a DCC, where the mutant protein exhibits both ciliary and non-ciliary functions and some, but not all, phenotypic features are caused by cilia dysfunction3. This evidence concerns the gene DCC and cystic kidney disease.