We first tested the human BPH-1 benign prostatic hyperplasia cell line and observed the pan-PI3K inhibitor BKM120 increased the proportion of ciliated cells (Fig. 5f), a phenomenon that occurred in the absence of accumulation of cells in G0/G1, the cell cycle phase where cilia assembly is promoted (Fig. 5g. Here, PIK3CA is linked to benign prostatic hyperplasia.