YBX1 has predictive value for drug resistance and poor prognosis in more than 20 cancer types, and upregulates the expression of multiple drug resistance genes, including ABCB1, MVP/LRP, TOP2A, CD44, CD49f, BCL2, and MYC [23], upon UV irradiation or Cisplatin treatment. The gene discussed is ABCB1; the disease is cancer.