Erdal et al. demonstrated that DNA-damaging agents induced higher Bloom syndrome (BLM) helicase and exonuclease 1 (EXO1) expression levels for DNA end resection but lower Trex1 expression levels for cytosolic DNA degradation, which led to the release of single-stranded DNA (ssDNA) fragments from the cell nucleus into the cytosol [14]. This evidence concerns the gene EXO1 and Down syndrome.