Gene set enrichment analysis (GSEA) of the RNA-seq data of 1016 NSCLC patient samples (519 lung adenocarcinoma, LUAD and 497 lung squamous cell carcinoma, LUSC) from TCGA database indicated that tumor tissue ICAM-1 expression level was positively correlated with pathways regulating NSCLC progression (Fig. 1C). Here, ICAM1 is linked to lung adenocarcinoma.