Similarly, re-expression of ICAM-1 cytoplasmic domain deletion mutant (ICAM-1ΔCyto) in ICAM-1–knockdown A549 and H1650 cells did not rescue the cell apoptotic phenotype (Fig. 4A, B), suggesting that the binding of FGG to ICAM-1 may activate an anti-apoptosis signaling in NSCLC cell through ICAM-1 intracellular signaling. This evidence concerns the gene ICAM1 and non-small cell lung carcinoma.