However, overexpression of ICAM-1Δ8-22 or ICAM-1ΔCyto mutant was unable to inhibit the activated caspase-9/3 signaling (Fig. 5A), indicating ICAM-1–FGG ligation and ICAM-1 intracellular signaling are crucial for the shut-down of caspase-9/3 signaling in NSCLC cells. This evidence concerns the gene CASP9 and non-small cell lung carcinoma.