In addition, it is reported that plasma FG enhances gallbladder cancer cell metastasis and extravasation through inducing ICAM-1 expression, which is accompanied by intensive pro-angiogenic macrophages recruitment, further facilitating angiogenesis in the tumor microenvironment [24], indicating that FG plays a role in potentiating tumor metastasis and angiogenesis by inducing ICAM-1 expression. Here, ICAM1 is linked to neoplasm.