ICAM1 and non-small cell lung carcinoma: Considering interference of ICAM-1‒FGG axis resulted in the suppressed ERK1/2 phosphorylation (Fig. 5C) and subsequent NSCLC cell apoptosis (Fig. 7C, D), we wondered whether blocking ICAM-1‒FGG interaction using JH12 mAb has synergistic effects in combination with recently developed potent ERK pathway small-molecule inhibitors.