FGG and non-small cell lung carcinoma: Although a previous study has revealed that FGA suppresses tumor growth and metastasis through association with integrin α5, the intact FG protein or FGG unlikely has similar effects on LUAD survival [25], which is consistent with our findings that tumor cell derived-FGG executes its anti-apoptosis functions when ligation to NSCLC cell surface-expressing ICAM-1.