Re-expression of WT ICAM-1 but not ICAM-1Δ8-22 mutant in ICAM-1–knockdown A549 and H1650 cells ameliorated the ICAM-1 knockdown-induced cell apoptosis (Fig. 4A, B), indicating the ICAM-1–FGG interaction is essential to the survival of NSCLC cells. Here, ICAM1 is linked to non-small cell lung carcinoma.