BRD2 and central congenital hypothyroidism: Reviewing data from previous case series, ACTH deficiency occurs in 0 to 5% of cases, TSH deficiency in 16 to 25% of cases, FSH/LH deficiency in 28 to 75% of cases, GHD in approximately 28% of cases, and AVP-D in 5 to 100% of cases ([141–143]).