The frequency of SAI ranges from 8 to 55% of patients affected by PitNETs, mainly in association with other pituitary hormone deficits, such as TSH deficiency (5%-42.5%), FSH/LH deficiency (4–62.4%), GH deficiency (2.3–60%), as shown in Table 4 ([59–63]). Here, BRD2 is linked to central congenital hypothyroidism.