POMC and central congenital hypothyroidism: The occurrence of ACTH deficiency (all diagnosed by 8 a.m. and/or random plasma cortisol and ACTH and ACTH test when necessary) is described in 22–75% of reported case series, TSH deficiency in 14%-75% of cases, FSH-LH deficiency in 31–75%, GH deficiency in 9–62% and AVP-D in 17–82% ([80, 81, 85–93]), with variable prevalence in patients with adeno-hypophysitis, infundibulo-neuro-hypophysitis or pan-hypophysitis [94].