Increased expression of key enzymes in the mevalonate pathway, such as squalene epoxidase and SREBPs, has already been identified as playing a pivotal role in advanced PCa.40, 41, 42 However, the specific relevance of SREBPs in the setting of docetaxel resistance in PCa, as well as the expression of SREBPs in mHSPC compared with mCRPC, has not yet been investigated, and represents a novelty of this work. This evidence concerns the gene SQLE and posterior cortical atrophy.