Sterol regulatory element binding proteins (SREBPs) are key regulators of cholesterol and lipid biosynthesis, and increased SREBP expression is associated with accelerated tumor progression in many malignancies, including PCa.20, 21, 22, 23 Importantly, SREBPs can directly interact with DNA binding sites and regulate the expression of other key enzymes in the mevalonate pathway, such as 3-hydroxy-3-methylglutaryl-coenzyme-A–reductase (HMGCoA-R), 3-hydroxy-3-methylglutaryl-coenzyme-A–synthase, or squalene epoxidase, as well as lipid metabolism.24 The gene discussed is SQLE; the disease is posterior cortical atrophy.