RFX6 and autoimmune polyendocrine syndrome type 1: used PhIP-seq to identify novel autoantibodies that target specific organs affected in patients, such as anti-KHDC3L autoantibodies, which target ovaries and are associated with primary ovarian insufficiency, and anti-RFX6 autoantibodies, which target the gut and are associated with diarrheal-type intestinal dysfunction in patients with APS1 (67).