TF and neoplasm: Furthermore, TF expression is induced following exposure to hypoxia, which is often seen in glioblastoma and was shown to enhance coagulation.83Indeed, in a small cohort of brain cancer patients (n = 96), Thaler et al observed widespread TF expression in glioblastoma tumor tissue using immunohistochemical staining.84However, only 56 glioblastoma patients were included in this cohort (58.3%), and no correlation was found between TF expression and VTE.