TF and neoplasm: Secretion of TF-bearing EVs by human glioblastoma cells was already described in 1984, being associated with platelet aggregation and thrombus formation.90In a small cohort of glioblastoma patients (n = 61), TF-EV levels were found to be particularly high prior to surgery, with a further increase up to 7 months afterwards.91Increased TF-EV levels at 7 months after surgery were associated with subtotal tumor resection and radiological disease progression.