Furthermore, high D-dimer plasma levels, elevated von Willebrand factor levels, and decreased clotting time were associated with increased hypercoagulability in glioblastoma patients as compared to patients with meningioma.126Another study described a 2.1-fold increased VTE risk in high-grade glioma patients, of which 85% with glioblastoma, with elevated FVIII activity.127A benefit of these coagulation markers is their current diagnostic use in the clinic, resulting in detection methods being widely available. This evidence concerns the gene F8 and central nervous system cancer.