• Upregulation of TF through Akt and Ras signaling in combination with hypoxia, which could be decreased uponPTENrestoration in glioblastoma cell lines LN229 and U-8787•PTENrestoration results in reduction ofEGFR-mediated TF expression in glioblastoma cell line U-87119• Increased expression of podoplanin through Akt signaling in glioblastoma cell lines LN18, LN229, LN428, U-87, and U-373121. The gene discussed is PDPN; the disease is glioblastoma.