TF and neoplasm: EGFRvIII shows low constitutive activity and ligand-independent signaling, mainly through RAS and mTOR, resulting in increased proliferation, migration, and invasion.106In 1994, EGFRvIII-expressing glioma cell lines were already reported to induce increased tumorigenesis in nude mice.110Glioblastoma cells expressing EGFRvIII demonstrate upregulation of TF as well as other procoagulant proteins, such as PAR1, PAR2, and FVII.111, 112Thus, constitutive signaling by EGFRvIII promotes tumor progression and a procoagulant microenvironment, suggesting a role in glioblastoma-related VTE.