This was confirmed in a recent cohort study with adult-type diffuse glioma (glioblastoma,IDH-wild-type vs. astrocytoma,IDH-mutant and oligodendroglioma,IDH-mutant and 1p/19q-codeleted), but no association was observed between the levels of circulating podoplanin and glioma subtype or cumulative VTE incidence.73Furthermore, Tawil et al reported increased platelet activation following injection of glioma-derived podoplanin-positive EVs in mice, but no significant increase in plasma D-dimer levels. This evidence concerns the gene PDPN and glioma.