TF is upregulated in virtually all cancer types, resulting in TF expression within the tumor as well as in the circulation on circulating tumor cells and tumor-cell secreted EVs.77This contributes to the hypercoagulable state in cancer patients, increasing the risk of VTE, but also induces tumor progression through TF-mediated PAR signaling.78Because of being involved in both cancer and coagulation, TF is generally accepted as a protagonist that connects cancer and VTE.79, 80. The gene discussed is TF; the disease is neoplasm.