EGFR is a transmembrane tyrosine kinase receptor involved in cell proliferation, differentiation, and migration.EGFRoverexpression contributes to tumor growth and EMT, being associated with invasion and metastasis.106TheEGFRgene is one of the most frequently mutated genes in glioblastoma, but less common in lower grade gliomas.107, 108It is estimated that up to 60% of glioblastoma tumors showEGFRupregulation, either caused by genomic amplification, rearrangement, and/or mutation.109This is especially the case in classical glioblastoma, which is characterized byEGFRamplification.100. Here, EGFR is linked to glioblastoma.