PDPN and central nervous system cancer: Importantly, an association has been described between mutations within the geneIDH1and decreased expression of podoplanin (see below).71Since all glioblastoma tumors demonstrateIDH-wild-type expression following the most recent World Health Organization (WHO) classification of tumors of the central nervous system (2021),72glioblastoma patients inherently show high podoplanin levels and an increased VTE risk compared to patients with lower grade gliomas.