PDPN and glioblastoma: Moreover, the risk of developing VTE also relies on genetic signature and subsequent procoagulant gene and protein expression, the so-called coagulome.14Tissue factor (TF), the primary initiator of the coagulation cascade, and podoplanin, involved in platelet aggregation, are often upregulated in glioblastoma and assumed to significantly increase the risk of VTE.