That is,EGFRamplification andPTENdeletion both induce RAS signaling, which is frequently overactivated in cancer and by itself induces a plethora of procoagulant effects, such as upregulation of pro-angiogenic VEGF or TF itself.83, 124Furthermore,TP53mutations are often observed in proneural glioblastoma, and are known to promote TF expression in combination with inactivating alterations in eitherPTENorCDKN2A. This evidence concerns the gene TF and glioblastoma.