TF and cancer: That is,EGFRamplification andPTENdeletion both induce RAS signaling, which is frequently overactivated in cancer and by itself induces a plethora of procoagulant effects, such as upregulation of pro-angiogenic VEGF or TF itself.83, 124Furthermore,TP53mutations are often observed in proneural glioblastoma, and are known to promote TF expression in combination with inactivating alterations in eitherPTENorCDKN2A.