F8 and thrombophilia: Furthermore, high D-dimer plasma levels, elevated von Willebrand factor levels, and decreased clotting time were associated with increased hypercoagulability in glioblastoma patients as compared to patients with meningioma.126Another study described a 2.1-fold increased VTE risk in high-grade glioma patients, of which 85% with glioblastoma, with elevated FVIII activity.127A benefit of these coagulation markers is their current diagnostic use in the clinic, resulting in detection methods being widely available.