In addition, a well-known homolog of ZNRF3, ring finger protein 43 (RNF43 [MIM: 612482]) with an ectodomain protein sequence identity of 39% to ZNRF3,17 is also negatively regulating Wnt signaling57 and is frequently mutated in several types of cancer58 but has not yet been causally linked to NDD. The gene discussed is RNF43; the disease is Neurodevelopmental delay.