Unlike WDFY3-associated macrocephaly where Wnt/β-catenin signaling was downregulated, Wnt/β-catenin signaling was enhanced for missense variants in ZNRF3 from the macrocephaly affected individuals, while decreased for the ZNRF3 missense variant from the microcephaly affected individual. The gene discussed is WDFY3; the disease is microcephaly.