It has been shown that znrf3 can be triggered by rspo2 to internalize and degrade the type I bone morphogenetic protein (BMP) receptor bmpr1a during the regulation of dorsoventral axis formation in Xenopus. 61Very recently, a study has reported the regulatory function of ZNRF3 for the epidermal growth factor receptor in cancer cell lines.62 This evidence concerns the gene EGFR and cancer.