This analysis suggested that intermediated traits such as obesity, the mammalian target of rapamycin, heme oxygenase-1 (an antioxidant with anti-inflammatory properties),28 and insulin are potential intermediate phenotypes that may inform the non-glycemic mediators of SGLT2 inhibitors on prostate cancer (Table S14). The gene discussed is HMOX1; the disease is obesity due to melanocortin 4 receptor deficiency.