LUCAT1 and neoplasm: In this study, we identified four glycolysis-associated lncRNAs (LUCAT1, LINC01138, LINC01605, and HOTAIR) by comprehensive multi-omics analysis and in vitro experiments and, based on these, developed a ccRCC prognostic characterization model, which predicts the prognostic risk of patients with ccRCC, the efficacy of immunotherapy and chemotherapy, and the role of lncRNAs tumor immune infiltration.