Chronic effects of incretin mimetics in diabetic subjects The 8-week administration of a short-acting GLP-1Ra lixisenatide elicits a natriuretic and urinary alkalizing response in overweight and inadequately controlled T2DM subjects, indicating a possible inhibition of sodium-hydrogen antiporter 3 activity in the proximal tubule mediated by GLP-1R. Here, GLP1R is linked to type 2 diabetes mellitus.