HNF4A and Alzheimer disease: Although the BDNF gene promoter contains binding motifs for Wnt-dependent TCF/LEF transcription factors [9], we did not observe significant changes in the protein content of this neurotrophin in the WT or in the 3xTg-AD mice, in agreement with other works in which 3xTg-AD mice were found to have BDNF levels that are comparable to those of WT controls [56].