To determine the activation status of canonical Wnt signaling in the hippocampus during aging and throughout the progression of AD-type pathology, we analyzed the levels of the canonical antagonist and agonist Dkk-1 and Wnt7a in female WT (C57BL/6) and 3xTg-AD mice at 4 different ages: young (3 months old), mature (6 months old), middle aged (9–12 months old) and old (18 months old). Here, DKK1 is linked to Alzheimer disease.