This mechanism supports a model in which the upregulation of Dkk-1 during aging and incipient AD-like pathology negatively regulates Wnt signaling and subsequently reduces the content of the LRP6 coreceptor, as we found here, worsening the Wnt molecular pathway that participates in synapse assembly and function in the mature brain [51, 52]. Here, LRP6 is linked to Alzheimer disease.