Upon analyzing the associations between CRP (P = 0.082), ESR (P = 0.366), C3 (P = 0.130), C4 (P = 0.317), and anti-ds-DNA antibody levels (P = 0.276) with the LE8 score, LE8 behavioral score, and LE8 factor score in SLE patients, we discovered that none of these markers exhibited a statistically significant correlation with the LE8 score. This evidence concerns the gene C4A and systemic lupus erythematosus.