ITGAV and colorectal cancer: For instance, ITGA11 is overexpressed in colon cancer samples when compared to normal adjacent tissue [33], while abnormal levels of ITGAV and ITGB6 in colorectal cancer has been associated with epithelial to mesenchymal transition, cancer progression, invasiveness, metastasis [34, 35] and a worse prognosis [29, 33, 35].