Downregulated proteins were associated with pathways of cardiomyopathy, extracellular matrix (ECM), cell adhesion, phosphatidylinositol-3-kinase/Akt (PI3K-Akt) and transforming growth factor beta (TGF-β) (Supplementary Fig. 3, Supplementary Table 3). This evidence concerns the gene AKT1 and cardiomyopathy.