In children with CD, substantial inter-reader agreement has been observed when using the sMaRIA (four readers: κ = 0.65, ICC = 0.71; P < 0.001 for both), and scores have been shown to correlate with the weighted pediatric Crohn’s disease activity index (wPCDAI) (ρ = 0.46, P < 0.001) and C-reactive protein (CRP) (ρ = 0.48; P < 0.001) [15]. This evidence concerns the gene CRP and Crohn disease.