F5 and thrombophilia: Notably, several studies reported VTE in all individuals with thrombophilia: FVL heterozygous [14–19], FVL homozygous [15, 20–44], FII heterozygous [17–19, 27], FII homozygous [17, 24, 31, 38, 39, 45–49], compound heterozygosity [35, 37, 50–53], PC deficiency [15, 17, 39, 54, 55], PS deficiency [17, 56], and AT deficiency [17, 35, 55–57].