IFNB1 and viral infectious disease: To analyse the effect of MC089 on innate immune signalling pathways in more detail, we employed a luciferase assay-based screening system, driving activation of virus-sensing pathways at defined points with PRR agonists, viral infection or overexpressed innate signalling proteins and measuring the effect of MC089 on activation of three distinct luciferase reporter constructs: κB-luciferase, ISRE-luciferase and IFNβ promoter-luciferase.