For example, in some T-acute lymphoblastic leukemias, elevated levels of other Phase 1 TFs like Lmo2, working as proto-oncogenes, are implicated in the developmentally frozen immature phenotype (Cleveland et al., 2013; Smith et al., 2014; Treanor et al., 2014), and a braking role for Lmo2 at natural levels is supported by our preliminary data as well (unpublished data). This evidence concerns the gene LMO2 and acute lymphoblastic leukemia.