Moreover, M5‐induced elevation of chemokines (CXCL1 and CXCL2), pro‐inflammatory cytokines (IL‐6 and TNF‐α), and anti‐microbial peptides (S100A7 and S100A8) were partly reversed following Rutin treatment, suggesting that Rutin treatment could mitigate psoriasis‐related inflammation. The gene discussed is S100A8; the disease is psoriasis.