Here, we found that WWP2 knockdown‐mediated reduction of WWP2 and YAP1 expression and elevation of LATS2 and p‐YAP1 levels in glioma cells was reversed by the combination of sh‐WWP2 and sh‐CMTM5 transfection (Figure 4F). This evidence concerns the gene YAP1 and central nervous system cancer.