Wu et al. (12) reported that TNF receptor-associated factor 6 (TRAF6) could lead to autophagic degradation of oncogenic β-catenin (CTNNB1) and overexpression of GSK3B in colorectal cancer (CRC) causing degradation of TRAF6, finally increasing the β-catenin level and promoting CRC metastasis. This evidence concerns the gene GSK3B and colorectal cancer.