SQSTM1 and non-small cell lung carcinoma: SQSTM1 is commonly used to indirectly reflect autophagic flux, a critical cellular process to monitor the dynamic process of autophagy.[18] Immunoblotting assays demonstrated that SQSTM1 levels were upregulated in NSCLC cells after the administration of ALO, suggesting that autophagic flux was blocked upon ALO treatment.