In various disease models, some studies have demonstrated that ALO activates the PI3K/Akt pathway,[39] while others indicate that ALO suppresses it.[40] Consequently, further investigation is necessary to elucidate whether ALO directly regulates the PI3K/Akt/mTOR signaling pathway in NSCLC cells and to understand the mechanisms involved. The gene discussed is AKT1; the disease is non-small cell lung carcinoma.