Further investigation into the expression patterns of ferroptosis‐related proteins revealed that while S. aureus and E. coli infections downregulated the ferroptosis‐suppressing protein GPX4, yet simultaneously elevated the levels of ferroptosis‐promoting proteins such as ACSL4, heme oxygenase (HO‐1), and Prostaglandin‐endoperoxide synthase 2 (PTGS2) (Figure 2E). The gene discussed is ACSL4; the disease is escherichia coli infection.