Previous studies identified the role of IRF7 in transcriptionally activating IFN‐α/β expression, which resists infection by pathogens.[27] In our study, we first found that TLR signaling and downstream IRF7 are involved in ferroptosis in BMSCs infected with S. aureus and E. coli by regulating ACSL4 expression, and IRF7 was the most upregulated transcriptional factor. This evidence concerns the gene IRF7 and infection.