SREBF1 and metabolic dysfunction-associated steatotic liver disease: Zhao et al. (2020) designed and developed polymer nanoparticles to encapsulate RAPA named NP-RAPA, with monomethoxy-poly (ethylene glycol) (mPEG) as the hydrophilic shell and poly (D, L-lactic-co-glycolic acid) (PLGA) as the backbone structure. Compared to free RAPA, NP-RAPA significantly improved the lipid homeostasis by reducing SREBP-1c mediated DNL, thus decreased the accumulation of low-density lipoproteins in the liver of diet-induced MASLD mice (Zhao et al., 2020).