In order to investigate the causal link between SGLT2 inhibitors and prostate cancer risk via circulating metabolites or metabolite ratios, we conducted a two-sample, two-step MR study to delve into the hypothetical metabolic pathways that might interconnect the pharmacological action of SGLT2 inhibitors with the development of prostate cancer. This evidence concerns the gene SLC5A2 and Familial prostate cancer.