Given this, we sought to uncover and characterise the PRM interactome of the RTKs epidermal growth factor receptor (EGFR), FGFR2 and ERBB2/HER2 in cell lines resembling oesophageal adenocarcinoma (OAC), breast adenocarcinoma (BrAC), glioblastoma (GBM) and lung squamous cell carcinoma (LSCC). The gene discussed is ERBB2; the disease is squamous cell lung carcinoma.