According to a recent study by Hao Huang et al. RTN3, a tubular endoplasmic reticulum protein, may interact with heat shock cognate protein 70 (HSC70) to reduce its function in chaperone-mediated lipophagy, which in turn may promote the enrichment of neutral lipids near plaques and mediate lipid accumulation in AD neuropathology [49]. The gene discussed is RTN3; the disease is Alzheimer disease.