Cancer cells can use this energy to continue to grow and proliferate, which has led to more and more attention to the role of lipophagy in cancer [3,[35], [36], [37]].Among the liver diseases most closely related to lipophagy, when the endoplasmic reticulum resident protein (Nogo-B) is overexpressed in NAFLD-related hepatocellular carcinoma, it can activate lipophagy, degrade TG, and increase the content of free fatty acids, inducing carcinogenicity [38]. Here, RTN4 is linked to cancer.