Another widely used lipid-lowering drug-atorvastatin, promotes lipophagy, cholesterol efflux, reduces lipid accumulation, and inhibits the formation of foam cells, the main pathological component of atherosclerosis, by upregulating AMPK phosphorylation and downregulating mammalian target of rapamycin phosphorylation [34]. The gene discussed is MTOR; the disease is atherosclerosis.