For example, EVs (rang from approximately 90-180 nm, mode 120 nm) derived from glioblastoma multiforme (GBM) have been reported to contain abundant proteins, including chondroitin sulfate proteoglycan 4, α-2-macroglobulin, cadherin, etc. Exposure to EVs in GBM can change the structure of cell surface proteins, promote the transformation of monocytes into M2 macrophages, and increase the expression of M2 macrophage marker CD163 [86]. This evidence concerns the gene CSPG4 and glioblastoma.