Tumor-derived EV miR-183–5p up-regulates macrophages expressing PD-L1 and promotes immunosuppression and disease progression in intrahepatic cholangiocarcinoma (ICC) through the miR-183–5p/PTEN/AKT/PD-L1 pathway [93]. The gene discussed is PTEN; the disease is intrahepatic cholangiocarcinoma.