CD63 and neoplasm: Tumor-derived exosomes (uniformly round or oval, size range of 30–120 nm, marker proteins CD81, CD63,TSG101) miR-146a-5p can activate the anti-oncogene WWC2-mediated Hippo-YAP signaling pathway and change the dynamics of F-actin/G-actin, eventually leading to CC metastasis [25].