It is important to emphasize that we selected pTau-181 as a candidate mediator of the effect of rs6859 in the NECTIN2 gene on AD because both pTau and the NECTIN2 gene have been linked to AD, as well as to infections, in the literature (Yashin et al., 2018; Sathler et al., 2022; Tang et al., 2022). The gene discussed is NECTIN2; the disease is Alzheimer disease.