It is important to note that a C3+ reactive astrocyte transformation has been observed in C9orf72, SOD1 and sALS human tissue samples in the spinal cord and motor cortex, indicating a neuroinflammatory astrogliosis as a common pathology in ALS (Guttenplan et al., 2020). This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.