For an example, human CREB5 protein, part of the CREB family, binds to CRE specifically with c-Jun or CRE-BP1 as a homodimer or heterodimer to function as a CRE-dependent trans-activator and act as an oncogene or biological marker in multiple cancers, particularly glioma (Wu et al., 2024). The gene discussed is CREB1; the disease is cancer.