The protein levels of AHNAK, CDC37, and SPTAN1 were significantly downregulated in JL-DCIS-3 vs JL-Contra-3 but were also significantly downregulated in the established late-stage BC cell lines MDA-MB231 and MCF-7 relative to JL-Contra-3 (AHNAK [p <0.00001 for both], CDC37 [p = 0.009, 0.006 respectively], SPTAN1 [p <0.00001 for both]). The gene discussed is SPTAN1; the disease is breast cancer.