ADAR safeguards against autoimmunity by suppressing pathways associated with cellular long dsRNA sensors, including antiviral RIG-I-like receptors, MDA5-MAVS pathway, Protein Kinase activated by RNA (PKR), and OAS-RNAses (Quinones-Valdez et al., 2019). This evidence concerns the gene EIF2AK2 and Autoimmunity.