CAV1 and non-small cell lung carcinoma: However, Huang’s experiments found that upregulation of CAV1 expression can trigger a certain degree of cisplatin resistance in NSCLC (Huang et al., 2019b), Dominic’s research also found that knocking out CAV1 can restore radiosensitivity in NSCLC cells exhibiting radiation resistance (Leiser et al., 2021), it was clearly stated that CAV1 had a certain degree of protective effect on NSCLC cells.