Furthermore, the altered microbiota representing gut dysbiosis in the SF-Soy-HFD group was predicted to be associated with key disease pathways, including inflammation, NF-κB and JNK signaling, lipopolysaccharide responses, Toll-like receptor signaling, NOD-like receptor signaling, inflammatory bowel disease, liver disease, atherosclerosis, and apoptosis. Here, MAPK8 is linked to atherosclerosis.