We observed high levels of interferon alpha (IFNA), 10kDa interferon gamma-induced protein (IP10), interleukin-6 (IL6), and cc-chemokine ligand 5 (CCL5) proteins in the supernatant (Figure 1D) as well as a pro-inflammatory transcriptional signature (Figure 1E) in A375 and YUMM1.7 melanoma cells after transfection of 3pRNA, which was largely unaffected by dabrafenib or trametinib (Figures 1D and 1E). Here, IL6 is linked to melanoma.