To test the effect of RIG-I stimulation in combination with BRAF/MEK inhibition in vivo, we used a spontaneous melanoma model, in which tamoxifen-induced Cre-mediated expression of the BRAF V600E variant and concomitant deletion of the Pten tumor suppressor induces melanoma within 2–12 months after treatment.25 The gene discussed is RIGI; the disease is melanoma.