CHD8 and Macrocephaly: Dysregulation of brain developmental processes due to multiple genomic variations in genes involved in cell proliferation (e.g., PTEN, mTOR pathway), chromatin remodeling (e.g., chromodomain helicase DNA binding protein 8, CHD8), protein transcription and translation and biological adhesion (WNT pathway) has been associated with ASD and macrocephaly (26–30), in order to provide elucidation of genotype–phenotype correlations and new insights into different subtypes of ASD.