TRPC1 and Familial prostate cancer: However, in most cancers, TRPC1 is associated with intracellular calcium ion regulation, and high expression of TRPC1 is associated with poor prognosis in patients with tumors, such as tongue squamous cell carcinoma, endometrial carcinoma, kidney cell carcinoma, colorectal cancer, breast cancer, stomach cancer, and prostate cancer [33–39].